Possible correlations between SH2B3 rs2078863 gene polymorphism, lifestyle, food habits and nutritional intake of Minangkabau females with hypertension

Background: Hypertension is the commonest cardiovascular risk factor and a leading cause of death worldwide. Several genetic variants are known to be involved in the pathogenesis of this disease. this study aimed to determine the relationship between the SH2B3 rs2078863 gene variants and hypertension in Minangkabau women.Methods: In total, 190 women aged 18-45 years old participated in this study. Patient data, including weight, height, Body Mass Index (BMI), and blood pressure examinations, were collected, and interviews regarding their nutrient intake and physical activity were assessed with the Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ) and the Global Physical Activity Questionnaire (GPAQ) questionnaires. Blood was collected from peripheral veins, followed by DNA isolation and genotyping examination using the Kompetitive Allele Specific PCR (KASP) method.Results: TT genotype in SH2B3 rs2078863 was observed to be more at risk of suffering from hypertension compared to the CC+CT genotype ((ꭓ2 (1, n=190)=8.442 p=.004, phi=.21, OR=2.48). The regression logistic analysis revealed the role of obesity, low physical activity, and age as risk factors for hypertension in the studied population (p<0.05).Conclusion: In conclusion, the SH2B3 gene variant and lifestyle factors related to obesity, and low physical activity, increase the risk of hypertension.