Key result
In Japanese women, the SLC12A1 CC genotype was significantly associated with a higher prevalence of hypertension compared to the TT + TC genotypes (OR 1.967; 95% CI 1.430-2.712; P<0.0001).
Why the study?
Are specific single-nucleotide polymorphisms of 22 candidate genes associated with hypertension in the Japanese general population?
Population
1880 subjects representing the general population in Japan, recruited from the Suita study
Comparison
118 single-nucleotide polymorphisms of 22… vs Alternative genotypes
Design
Cross-sectional
Authors
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Hypothesis-generating for SLC12A1 in Japanese women; requires prospective validation before any clinical consideration.
Observational (n=1,880)
Are specific single-nucleotide polymorphisms of 22 candidate genes associated with hypertension in the Japanese general population?
Odds Ratio: 1.967 (95% CI 1.43–2.712)
p-value: p=<0.0001
A polymorphism in the SLC12A1 gene is significantly associated with an increased risk of hypertension in Japanese women.
Iwai et al. (2004) conducted an observational in Hypertension (n=1,880). SLC12A1 CC genotype vs. TT + TC genotypes was evaluated on Hypertension (OR 1.967, 95% CI 1.430-2.712, p=<0.0001). In Japanese women, the SLC12A1 CC genotype was significantly associated with a higher prevalence of hypertension compared to the TT + TC genotypes (OR 1.967; 95% CI 1.430-2.712; P<0.0001).
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