Key result
Combined genotypes of ITGA2, GCK, and PTGIS were associated with a lower prevalence of hypertension (OR 0.47), present in 1.1% of hypertensive and 2.0% of control individuals.
Why the study?
Are specific gene polymorphisms associated with the risk of hypertension in Japanese individuals?
Population
4853 unrelated Japanese individuals, including 2818 subjects with hypertension and 2035 controls.
Comparison
Genotyping for 150 polymorphisms of 128… vs Control individuals without hypertension.
Design
Case-control
Authors
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May inform genetic risk models in Japanese hypertension; leaves open causality and needs prospective validation.
Case-Control (n=4,853)
Are specific gene polymorphisms associated with the risk of hypertension in Japanese individuals?
Odds Ratio: 0.47
Absolute Event Rate: 1.1% vs 2%
p-value: p=< .01
Specific genotypes for ITGA2, GCK, and PTGIS are significantly associated with hypertension in Japanese individuals, potentially aiding in personalized prevention strategies.
Yamada et al. (2006) conducted a case-control in hypertension (n=4,853). Combined genotypes of ITGA2, GCK, and PTGIS vs. Other genotypes was evaluated on Hypertension (OR 0.47, p=< .01). Combined genotypes of ITGA2, GCK, and PTGIS were associated with a lower prevalence of hypertension (OR 0.47), present in 1.1% of hypertensive and 2.0% of control individuals.
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