Key result
The RGS2 1891-1892del TC polymorphism (OR 1.10) and the CYP4A11 T8590C polymorphism (OR 1.19) were significantly associated with an increased risk of hypertension.
Why the study?
Are specific genetic variants (CYP4A11, RGS2, HTR2A, GNAS, HSD3B1) associated with an increased risk of hypertension?
Meta-Analysis (n=33,064)
Are specific genetic variants (CYP4A11, RGS2, HTR2A, GNAS, HSD3B1) associated with an increased risk of hypertension?
Odds Ratio: 1.1 (95% CI 1.02–1.19)
p-value: p=0.02
The RGS2 1891-1892del TC and CYP4A11 T8590C polymorphisms are associated with a modestly increased risk of hypertension.
May modestly inform hypertension susceptibility research; hypothesis-generating and should not yet change clinical practice.
AIMS: The aim of this study was to perform combined analyses of six genetic variants for the risk of hypertension. METHODS: After a comprehensive literature search for genetic variants involved with the association study of hypertension, we harvested a total of five genes (six variants) for the current meta-analyses. These genes consisted of CYP4A11 (T8590C), RGS2 (1891-1892del TC and G638A), HTR2A (T102C), GNAS (T393C), and HSD3B1 (T→C Leu338). RESULTS: A total of 20 studies among 13,816 cases and 19,248 controls were retrieved for the meta-analyses of six genetic variants. It was shown that the RGS2 1891-1892del TC (OR=1.10, 95% CI=1.02-1.19, p=0.02) polymorphism and the CYP4A11 T8590C (OR=1.19, 95% CI=1.00-1.41, p=0.05) polymorphism were significantly associated with increased risk of hypertension. No association was found between the other four variants and the risk of hypertension. CONCLUSION: This meta-analysis revealed that the RGS2 1891-1892del TC polymorphism and CYP4A11 T8590C polymorphism were associated with hypertension risk. However, HSD3B1 T→C Leu338, HTR2A T102C, GNAS T393C, and RGS2 G638A polymorphisms were not associated with hypertension risk.
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Zhang et al. (2013) conducted a meta-analysis in Hypertension (n=33,064). RGS2 1891-1892del TC polymorphism vs. Absence of polymorphism was evaluated on Risk of hypertension (OR 1.10, 95% CI 1.02-1.19, p=0.02). The RGS2 1891-1892del TC polymorphism (OR 1.10) and the CYP4A11 T8590C polymorphism (OR 1.19) were significantly associated with an increased risk of hypertension.
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