Key result
HTR2A genetic variations were significantly associated with hypertension risk, with the rs4941573TC genotype increasing the odds of hypertension by 1.327 times compared to the TT genotype.
Why the study?
Hypertension is a risk factor for obesity-related cardiovascular diseases, prompting investigation into whether genetic variations in the serotonin 2A receptor (HTR2A) are associated with hypertension.
Are genetic variations in the serotonin 2A receptor (HTR2A) associated with the risk of hypertension in Korean adults?
Cross-Sectional (n=13,563)
Yes
Are genetic variations in the serotonin 2A receptor (HTR2A) associated with the risk of hypertension in Korean adults?
Odds Ratio: 1.327 (95% CI 1.101–1.599)
p-value: p=0.003
Specific genetic variations in the serotonin 2A receptor (HTR2A) gene are associated with an altered risk of hypertension in the Korean population.
No immediate change to hypertension management; hypothesis-generating for HTR2A in genetic risk research.
BACKGROUND: Hypertension is one of the risk factors for obesity-related cardiovascular diseases. We investigated whether genetic variations in serotonin 2A receptor (HTR2A) were associated with hypertension. METHODS: We carried out a cross-sectional study in cohorts A (Ansan-Ansung cohort, N = 6039) and B (Wonju-Pyengchang cohort, N = 7524). Several genetic variants in HTR2A including rs7330636, rs9590999, rs2183057, and rs4942595 were selected and genotyped. RESULTS: , respectively, which were higher than in those without hypertension (p < 0.001). rs4942595TC genotype was associated with hypertension in cohort A (OR = 0.739), after adjusting for variables. Subjects with rs4942578AA genotype had a decreased risk of hypertension after adjusting for clinical factor (OR = 0.735) in cohort B, and an elevated risk of hypertension in cohort A (OR = 1.562). The logistic regression analysis showed that participants with rs4941573TC genotype were 1.327 times more likely to have a higher blood pressure than those with TT genotype (95% CI 1.101-1.599) in cohort B. Whereas, the OR for developing hypertension in subjects with rs17069883CC genotype compared to those with AA genotype was 1.447 (95% CI 1.018-2.056; p for trend = 0.040) in cohort A. CONCLUSIONS: HTR2A genetic variations were associated with hypertension risk in our study.
No takes yet. Share an insight, caveat, or question.
Choi et al. (2020) conducted a cross-sectional in Hypertension (n=13,563). HTR2A genetic variations (e.g., rs4941573) vs. Reference genotypes (e.g., TT genotype) was evaluated on Hypertension (OR 1.327, 95% CI 1.101-1.599, p=0.003). HTR2A genetic variations were significantly associated with hypertension risk, with the rs4941573TC genotype increasing the odds of hypertension by 1.327 times compared to the TT genotype.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: