Key result
HSD3B1 gene polymorphisms, specifically rs6203 and the T-C haplotype, were significantly associated with essential hypertension (P=0.030 and P=0.014, respectively).
Why the study?
Are HSD3B1 and HSD3B2 gene polymorphisms associated with essential hypertension, aldosterone levels, and left ventricular hypertrophy?
Population
275 patients with essential hypertension and 286 controls. Aldosterone levels were investigated in 240…
Comparison
HSD3B1 gene variations and HSD3B2 gene variations vs Controls without essential hypertension and…
Design
Case-control
Authors
Loading...
HSD3B1 variants may link to hypertension risk; hypothesis-generating and requires prospective validation before clinical or mechanistic conclusions.
Case-Control (n=561)
Are HSD3B1 and HSD3B2 gene polymorphisms associated with essential hypertension, aldosterone levels, and left ventricular hypertrophy?
p-value: p=0.030
Polymorphisms in the HSD3B1 gene, specifically rs6203 and rs1047303, are associated with essential hypertension, higher blood pressure, and elevated aldosterone levels.
Shimodaira et al. (2010) conducted a case-control in Essential hypertension (n=561). HSD3B1 and HSD3B2 gene polymorphisms vs. Controls without the specific polymorphisms or haplotypes was evaluated on Essential hypertension (p=0.030). HSD3B1 gene polymorphisms, specifically rs6203 and the T-C haplotype, were significantly associated with essential hypertension (P=0.030 and P=0.014, respectively).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: