Why the study?
Is the HSD3B1 gene associated with aldosterone production or blood pressure?
Population
Adrenocortical tissues, primary adrenal cell cultures, and 4 Dutch cohorts for genetic association analysis.
Design
Meta-analysis
Authors
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HSD3B1 should not guide hypertension evaluation or therapy; confirms HSD3B2 as the primary driver of adrenocortical steroidogenesis.
Is the HSD3B1 gene associated with aldosterone production or blood pressure?
HSD3B1 is not involved in aldosterone synthesis in the human adrenal cortex, nor does its genetic variation affect blood pressure, supporting the hypothesis that HSD3B2 drives adrenocortical steroidogenesis.
Verwoert et al. (2014) studied this question.
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