Key result
Isoform-specific monoclonal antibodies revealed that IHA features robust HSD3B1 expression in the zona glomerulosa, whereas APA tumor cells dominantly express HSD3B2.
Population
Normal human adrenal cortex and adrenal specimens from patients with primary aldosteronism
Design
Preclinical
Authors
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May support immunohistochemical distinction of IHA from APA; leaves open clinical utility pending validation.
Isoform-specific monoclonal antibodies against HSD3B1 and HSD3B2 reveal distinct expression patterns that may allow for accurate immunohistochemical differentiation between aldosterone-producing adenoma and idiopathic hyperaldosteronism.
Doi et al. (2013) studied Primary aldosteronism. Isoform-specific monoclonal antibodies against HSD3B1 and HSD3B2 was evaluated on Immunolocalization of HSD3B1 and HSD3B2 in normal human adrenal cortex and adrenal specimens from APA and IHA. Isoform-specific monoclonal antibodies revealed that IHA features robust HSD3B1 expression in the zona glomerulosa, whereas APA tumor cells dominantly express HSD3B2.
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