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March 3, 2016Current Opinion in Endocrinology Diabetes and ObesityOpen Access

Immunohistochemistry of the adrenal in primary aldosteronism

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Population

Aldosterone-producing adenomas (APA) and surrounding adrenal tissue in primary aldosteronism

Design

Review

Authors

CGCelso E. Gómez-SánchezEGElise P. Gómez-Sánchez

Discussion

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Overview

Mutations in APA ion channels extend molecular insights; leaves open any role in diagnosis or targeted therapy.

Structured PICO

P
Population
Aldosterone-producing adenomas (APA) and surrounding adrenal tissue in primary aldosteronism
I
Intervention
Immunohistochemistry using specific antibodies against CYP11B2 and CYP11B1 enzymes
O
Outcome
Expression of steroidogenic enzymes and histological/molecular structure

Immunohistochemical studies reveal significant structural and molecular complexity in aldosterone-producing adenomas and adjacent adrenal tissue, enhancing our understanding of the pathophysiology of primary aldosteronism.

Cite This Study

Gómez-Sánchez et al. (2016) studied this question.

synapsesocial.com/papers/6a70f3926ceb2bbd16e00959https://doi.org/10.1097/med.0000000000000248
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Case Report: Nodule Development From Subcapsular Aldosterone-Producing Cell Clusters Causes Hyperaldosteronism2015 · 80 citations
  2. 2Clinical Characteristics of Somatic Mutations in Chinese Patients With Aldosterone-Producing Adenoma2015 · 151 citations
  3. 3Different Somatic Mutations in Multinodular Adrenals With Aldosterone-Producing Adenoma2015 · 65 citations
  4. 4Expression and Mutations of KCNJ5 mRNA in Japanese Patients with Aldosterone-Producing Adenomas2012 · 176 citations
  5. 5Success of Surgery for Primary Aldosteronism Judged by Residual Autonomous Aldosterone Production1998 · 96 citations