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January 20, 2011European Journal of Endocrinology

Gene expression profiles in aldosterone-producing adenomas and adjacent adrenal glands

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Key result

Aldosterone-producing adenomas showed significantly higher expression of 14 genes, including CYP11B2 (P<0.001), compared to adjacent adrenal glands.

Population

10 aldosterone-producing adenomas (APA) and 10 adjacent adrenal glands (AAG) from the same adrenal

Comparison

Transcriptome analysis using microarray and… vs Adjacent adrenal gland (AAG) from the same adrenal

Design

Preclinical

Authors

TWTao WangFSFumitoshi SatohRMRyo Morimoto

Discussion

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Overview

Highlights candidate genes for primary aldosteronism; hypothesis-generating in animal models and requires human validation before clinical relevance.

Study Design

Type

Observational (n=10)

Structured PICO

P
Population
10 patients with primary aldosteronism providing paired aldosterone-producing adenoma and adjacent adrenal gland tissue samples.
E
Exposure
Transcriptome analysis using microarray and real-time quantitative RT-PCR (qPCR)
C
Comparator
Adjacent adrenal gland (AAG) from the same adrenal
O
Outcome
Differences in transcript profiles (gene expression) between APA and AAGsurrogate

Main Result

p-value: p=<0.001

Transcriptome analysis identifies novel genes associated with the aldosterone-producing adenoma phenotype, providing candidates for understanding the molecular mechanisms of primary aldosteronism.

Cite This Study

Wang et al. (2011) conducted an observational in Primary aldosteronism (n=10). Aldosterone-producing adenoma (APA) tissue vs. Adjacent adrenal gland (AAG) tissue was evaluated on Gene expression profiles (p=<0.001). Aldosterone-producing adenomas showed significantly higher expression of 14 genes, including CYP11B2 (P<0.001), compared to adjacent adrenal glands.

synapsesocial.com/papers/6a9a89761c51d4e2d58de16chttps://doi.org/10.1530/eje-10-1085
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Steroidogenesis in Aldosterone-Producing Adenoma Revisited by Transcriptome Analysis2005 · 32 citations
  2. 2Transcriptomics, Epigenetics, and Metabolomics of Primary Aldosteronism2021 · 14 citations
  3. 3Gene Expression Profile of Persistent Postoperative Hypertension Patients with Aldosterone-producing Adenomas2015 · 5 citations
  4. 4Elevated Expression of Luteinizing Hormone Receptor in Aldosterone-Producing Adenomas2006 · 105 citations
  5. 5Immunohistochemistry of the adrenal in primary aldosteronism2016 · 19 citations