Why the study?
Understanding the pathophysiological background of primary aldosteronism is important to provide ameliorative treatment strategies, with significant recent progress in clarifying the genetic and molecular mechanisms of aldosterone-producing adenomas.
Population
Human studies of primary aldosteronism subjects
Comparison
Transcriptomic, epigenetic, or metabolomic analyses
Design
Systematic review
Key result
Transcriptomic and metabolomic profiling revealed distinct transcriptional and steroidogenic patterns that distinguish aldosterone-producing adenomas with a KCNJ5 mutation from those with other mutations.
Authors
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Highlights mutational heterogeneity in APA; leaves open whether molecular profiling improves diagnosis or outcomes.
Systematic Review
Distinct transcriptomic and metabolomic patterns, particularly based on KCNJ5 mutation status, may contribute to personalized treatment strategies for primary aldosteronism.
Spyroglou et al. (2021) conducted a systematic review in Primary aldosteronism. Transcriptomic, epigenetic, and metabolomic profiling was evaluated on Transcriptomic, epigenetic, and metabolomic patterns. Transcriptomic and metabolomic profiling revealed distinct transcriptional and steroidogenic patterns that distinguish aldosterone-producing adenomas with a KCNJ5 mutation from those with other mutations.
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