Key result
Primary aldosteronism is linked to distinct gene and metabolite profiles involving 3 altered lipid pathways.
Why the study?
Primary aldosteronism is the most common secondary hypertension, and metabolic perturbations in PA remain to be elucidated to identify new targets and understand its biology.
What are the transcriptomic and metabolomic signatures and altered metabolic pathways in patients with primary aldosteronism compared to healthy controls?
Case-Control (n=48)
What are the transcriptomic and metabolomic signatures and altered metabolic pathways in patients with primary aldosteronism compared to healthy controls?
Combined metabolomic and transcriptomic analysis reveals distinct lipid metabolic pathway alterations in primary aldosteronism, providing potential new therapeutic targets.
Answers are grounded in this paper and cite their sources.
May identify lipid targets in primary aldosteronism; leaves open prospective validation before clinical adoption.
OBJECTIVE: Primary aldosteronism (PA) is the most common secondary hypertension. In this study, we performed the pathway enrichment analysis based on metabolomics and transcriptomic data to find the metabolic perturbations in PA, which could provide new targets for PA and further understand the biology of PA. METHODS: 24 PA patients and 24 healthy adults served as the control group in this study. Six participants were chosen from each group to have their peripheral blood and serum samples analyzed for omics investigations. Another eighteen participants' peripheral blood samples were selected for further validation of the RNA-sequencing results. RESULTS: Transcriptomic analyses found 518 differentially expressed genes (DEGs), and 339 remarkably differential metabolites (DMs) were identified by untargeted metabolomics. The pathway enrichment analysis was performed by combining with the omics analysis data. We also focused on analyzing metabolic pathways that repeatedly occur and constructed possible genemetabolic networks. A total of 5 genes and 11 metabolites showed significant changes in altered 3 lipid metabolic pathways. Furthermore, the expressions of these genes were verified by qRT-PCR. CONCLUSION: The combination of metabolomic and transcriptomic data can give a comprehensive picture of unique illness markers and preliminary knowledge of the molecular abnormalities underpinning PA. These findings may point to viable targets for creating treatments.
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Lai et al. (2025) conducted a case-control in Primary aldosteronism (n=48). Primary aldosteronism vs. Healthy adults was evaluated on Differentially expressed genes and differential metabolites. Primary aldosteronism was associated with 518 differentially expressed genes and 339 differential metabolites compared to healthy controls, highlighting alterations in 3 lipid metabolic pathways.
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