Key result
The -344C allele in the aldosterone synthase gene promoter was associated with elevated plasma aldosterone (129 pg/mL for CC vs 90 pg/mL for TT; P<0.002) and increased arterial stiffness.
Why the study?
Is the T-344C polymorphism in the aldosterone synthase gene associated with differences in plasma aldosterone levels and arterial stiffness in patients with essential hypertension?
Population
216 subjects of European origin with essential hypertension, evaluated during a 1-day hospitalization after…
Comparison
Presence of the -344C allele and T4986C… vs TT genotype and other genotypes
Design
Cross-sectional
Authors
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Hypothesis-generating for genetic influences on stiffness in hypertension; leaves open causality and any clinical role.
Cross-Sectional (n=216)
Is the T-344C polymorphism in the aldosterone synthase gene associated with differences in plasma aldosterone levels and arterial stiffness in patients with essential hypertension?
p-value: p=< .002
A variant in the promoter region of the aldosterone synthase gene (-344C allele) is associated with higher plasma aldosterone levels and increased arterial stiffness in patients with essential hypertension.
Pojoga et al. (1998) conducted a cross-sectional in Essential hypertension (n=216). CYP11B2 gene variations (T-344C and T4986C) vs. Different genotypes was evaluated on Plasma aldosterone levels (p=< .002). The -344C allele in the aldosterone synthase gene promoter was associated with elevated plasma aldosterone (129 pg/mL for CC vs 90 pg/mL for TT; P<0.002) and increased arterial stiffness.
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