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April 25, 2006Hypertension

Association Study With 33 Single-Nucleotide Polymorphisms in 11 Candidate Genes for Hypertension in Chinese

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Why the study?

Are specific single-nucleotide polymorphisms and gene-gene interactions associated with essential hypertension in Chinese subjects?

Population

993 Chinese subjects, comprising 503 patients with essential hypertension and 490 age- and gender-matched…

Comparison

Evaluation of 33 single-nucleotide polymorphisms… vs Age- and gender-matched controls without…

Design

Case-control

Authors

DGDongfeng GuPreventive CardiologySSShaoyong SuPreventive CardiologyDGDongliang GeNanjing Agricultural University

Discussion

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Overview

Supports multigenic etiology in Chinese subjects; hypothesis-generating and requires prospective validation before any clinical application.

Structured PICO

Are specific single-nucleotide polymorphisms and gene-gene interactions associated with essential hypertension in Chinese subjects?

P
Population
993 Chinese subjects, comprising 503 patients with essential hypertension and 490 age- and gender-matched controls
I
Intervention
Evaluation of 33 single-nucleotide polymorphisms in 11 candidate genes from biochemical pathways implicated in hypertension
C
Comparator
Age- and gender-matched controls without hypertension
O
Outcome
Association with essential hypertension (single-locus and multilocus effects)

Specific genetic polymorphisms and gene-gene interactions are associated with essential hypertension in Chinese populations, supporting a multigenic etiology.

Cite This Study

Gu et al. (2006) studied this question.

synapsesocial.com/papers/6a817aeb8fb9cc96313be665https://doi.org/10.1161/01.hyp.0000219041.66702.45
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  4. 4Combinations of Variations in Multiple Genes Are Associated With Hypertension2000 · 146 citations
  5. 5Evidence for linkage and association of the markers near the LPL gene with hypertension in Chinese families2003 · 18 citations