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January 1, 2004Human Heredity

Multilocus Analysis of Hypertension: A Hierarchical Approach

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Why the study?

Do epistatic interactions among candidate genes predict hypertension susceptibility in subjects from Ghana?

Population

Subjects from Ghana in a case-control design (hypertensive vs normotensive)

Comparison

Evaluation of 13 polymorphisms in 8 candidate… vs Normotensive subjects

Design

Case-control

Authors

SWScott M. WilliamsCase Western Reserve UniversityMRMarylyn D. RitchieBroad InstituteEDE.P. DawsonBioVentures (United States)

Discussion

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Overview

Epistatic ACE-GRK4 effects may contribute to hypertension risk in this cohort; leaves open replication, causality, and broader applicability.

Structured PICO

Do epistatic interactions among candidate genes predict hypertension susceptibility in subjects from Ghana?

P
Population
Subjects from Ghana in a case-control design (hypertensive vs normotensive)
I
Intervention
Evaluation of 13 polymorphisms in 8 candidate genes related to blood pressure regulation (including angiotensinogen, ACE, angiotensin II receptor, and GRK4)
C
Comparator
Normotensive subjects
O
Outcome
Blood pressure phenotype (hypertension susceptibility) based on single locus and multilocus genetic associations

Epistatic interactions between multiple genetic loci, specifically ACE and GRK4, play a significant role in hypertension susceptibility, suggesting that multiple physiological pathways must be affected to predispose to the disease.

Cite This Study

Williams et al. (2004) studied this question.

synapsesocial.com/papers/6a82bae9040bdabcf346feb2https://doi.org/10.1159/000077387
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  5. 5Identification of Hypertension-Susceptibility Genes and Pathways by a Systemic Multiple Candidate Gene Approach: The Millennium Genome Project for Hypertension2008 · 69 citations