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January 1, 2012International Journal of HypertensionOpen Access

Multilocus Family-Based Association Analysis of Seven Candidate Polymorphisms with Essential Hypertension in an African-Derived Semi-Isolated Brazilian Population

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Why the study?

Are seven candidate polymorphisms associated with essential hypertension and blood pressure levels in an African-derived semi-isolated Brazilian population?

Population

652 participants (97 families) from African-derived semi-isolated Brazilian populations (quilombos)

Design

Other

Authors

LKLuiz Koiti KimuraUniversidade de São PauloCACláudia Blanes AngeliEvotec (United States)MAM. T. B. M. AuricchioUniversidade de São Paulo

Discussion

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Overview

Does not support individual variant testing for EH or BP; leaves open marginal multilocus GNB3 effects on DBP for replication.

Structured PICO

Are seven candidate polymorphisms associated with essential hypertension and blood pressure levels in an African-derived semi-isolated Brazilian population?

P
Population
652 participants (97 families) from African-derived semi-isolated Brazilian populations (quilombos)
I
Intervention
Seven candidate polymorphisms (ACE rs1799752, AGT rs669, ADD2 rs3755351, NOS3 rs1799983, GNB3 rs5441 and rs5443, and GRK4 rs1801058)
O
Outcome
Systolic and diastolic blood pressure levels and essential hypertension (as a binary outcome)surrogate

There is limited evidence for multilocus effects of the studied candidate polymorphisms on blood pressure in African-derived semi-isolated Brazilian populations.

Limitations

  • Small sample size requiring further larger studies for validation

Cite This Study

Kimura et al. (2012) studied this question.

synapsesocial.com/papers/6a212c91c4e60624665ac46dhttps://doi.org/10.1155/2012/859219
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