Why the study?
Are ACE, AGT, and NOS3 gene polymorphisms associated with resistant hypertension?
Population
220 subjects including 70 resistant hypertensive patients, 80 well-controlled hypertensive patients, and 70…
Comparison
Genotyping for ACE insertion/deletion, AGT… vs Normotensive controls and well-controlled…
Design
Case-control
Authors
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AGT 235T association with resistant hypertension after age 50 is hypothesis-generating; leaves open whether genotyping informs management.
Are ACE, AGT, and NOS3 gene polymorphisms associated with resistant hypertension?
The AGT 235T allele is an independent risk factor for resistant hypertension, particularly in patients older than 50 years, highlighting the role of gene-environment interactions.
Yugar‐Toledo et al. (2011) studied this question.
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