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December 1, 2010Clinical and Translational Science

Variants in Genes Involved in Functional Pathways Associated with Hypertension in African Americans

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Why the study?

Are variants in GRK4, NOS3, or ACE genes associated with essential hypertension in African Americans aged 18-49 years?

Population

412 African Americans aged 18-49 years, comprising 173 with essential hypertension and 239 normotensives…

Comparison

Genetic variants in the G-protein coupled… vs Normotensive controls and alternative genotypes

Design

Case-control

Authors

MCMaria P. Martinez CantarinFundación Juan MarchAEAdam ErtelThomas Jefferson UniversitySDStephanie DeLoachThomas Jefferson University

Discussion

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Overview

These associations should not alter clinical practice; hypothesis-generating and requires replication in larger cohorts.

Structured PICO

Are variants in GRK4, NOS3, or ACE genes associated with essential hypertension in African Americans aged 18-49 years?

P
Population
412 African Americans aged 18-49 years, comprising 173 with essential hypertension and 239 normotensives, stratified into obese and nonobese groups.
I
Intervention
Genetic variants in the G-protein coupled receptor Kinase-4 (GRK4), nitric oxide synthase-3 (NOS3), and angiotensin converting enzyme (ACE) genes
C
Comparator
Normotensive controls and alternative genotypes
O
Outcome
Essential hypertension (HBP) status

Genetic variants in GRK4 and NOS3 show modest associations with essential hypertension in young to middle-aged African Americans, though effects are small and require further replication.

Limitations

  • Very modest effects
  • Do not fully replicate previous studies

Cite This Study

Cantarin et al. (2010) studied this question.

synapsesocial.com/papers/6a82bae7040bdabcf346feachttps://doi.org/10.1111/j.1752-8062.2010.00242.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multilocus Analysis of Hypertension: A Hierarchical Approach2004 · 131 citations
  2. 2Frequency of a Deletion Polymorphism in the Gene for Angiotensin Converting Enzyme Is Increased in African-Americans With Hypertension1994 · 138 citations
  3. 3Polymorphisms ofEDNRB,ATG, andACEgenes in salt-sensitive hypertensionThis article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin.2008 · 39 citations
  4. 4Endothelial nitric oxide synthase polymorphisms are associated with hypertension and cardiovascular disease in renal transplantation2008 · 11 citations
  5. 5Recommendations for Blood Pressure Measurement in Humans and Experimental Animals2005 · 4,003 citations