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July 1, 2000HypertensionOpen Access

Combinations of Variations in Multiple Genes Are Associated With Hypertension

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Why the study?

Are combinations of variations in multiple genes associated with hypertension?

Population

51 normotensive and 126 hypertensive age-matched individuals (total n=177)

Comparison

Analysis of interactions of alleles at 4… vs Normotensive individuals (control group)

Design

Case-control

Authors

SWScott M. WilliamsCase Western Reserve UniversityJAJonathan H. AddyMeharry Medical CollegeMDMin DaiTongji University

Discussion

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Overview

May support multilocus genetic interactions in hypertension; hypothesis-generating and requires replication before clinical or research adoption.

Structured PICO

Are combinations of variations in multiple genes associated with hypertension?

P
Population
51 normotensive and 126 hypertensive age-matched individuals (total n=177)
I
Intervention
Analysis of interactions of alleles at 4 candidate loci (angiotensinogen, ACE, angiotensin II type 1 receptor, and FJ)
C
Comparator
Normotensive individuals (control group)
O
Outcome
Association of multilocus genetic variations (linkage disequilibrium) with hypertensionsurrogate

Genetic interactions between multiple loci, rather than single-gene variants, appear to underlie the genetic basis of hypertension, potentially explaining inconsistencies in previous single-locus studies.

Cite This Study

Williams et al. (2000) studied this question.

synapsesocial.com/papers/6a82bae9040bdabcf346febahttps://doi.org/10.1161/01.hyp.36.1.2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Linkage Analysis of Candidate Genes and Gene-Gene Interactions in Chinese Hypertensive Sib Pairs1999 · 49 citations
  2. 2Polymorphism of the angiotensin I converting enzyme gene is apparently not related to high blood pressure: Dutch Hypertension and Offspring Study1993 · 188 citations
  3. 3Frequency of a Deletion Polymorphism in the Gene for Angiotensin Converting Enzyme Is Increased in African-Americans With Hypertension1994 · 138 citations
  4. 4Mistyping ACE heterozygotes.1993 · 512 citations
  5. 5Evidence for Involvement of the Type 1 Angiotensin II Receptor Locus in Essential Hypertension1999 · 167 citations