Key result
The rs4305 polymorphism in the ACE gene was associated with essential hypertension, and its interaction with a body mass index ≥25 further increased disease susceptibility.
Why the study?
Do polymorphisms in the Renin-Angiotensin-Aldosterone System (RAAS) genes associate with essential hypertension in the Han Chinese population?
Case-Control (n=1,810)
Do polymorphisms in the Renin-Angiotensin-Aldosterone System (RAAS) genes associate with essential hypertension in the Han Chinese population?
Specific genetic variants in the RAAS genes, along with non-genetic factors like BMI, significantly influence the susceptibility to essential hypertension in the Han Chinese population.
Answers are grounded in this paper and cite their sources.
Should not change hypertension management; extends RAAS polymorphism data in Han Chinese but remains hypothesis-generating.
BACKGROUND: Renin-angiotensin-aldosterone system (RAAS) is the most important endocrine blood pressure control mechanism in our body, genes encoding components of this system have been strong candidates for the investigation of the genetic basis of hypertension. However, previous studies mainly focused on limited polymorphisms, thus we carried out a case-control study in the Han Chinese population to systemically investigate the association between polymorphisms in the RAAS genes and essential hypertension. METHODS: 905 essential hypertensive cases and 905 normotensive controls were recruited based on stringent inclusion and exclusion criteria. All 41 tagSNPs within RAAS genes were retrieved from HapMap, and the genotyping was performed using the GenomeLab SNPstream Genotyping System. Logistic regression analysis, Multifactor dimensionality reduction (MDR), stratified analysis and crossover analysis were used to identify and characterize interactions among the SNPs and the non-genetic factors. RESULTS: Serum levels of total cholesterol (TC) and triglyceride (TG), and body mass index (BMI) were significantly higher in the hypertensive group than in the control group. Of 41 SNPs genotyped, rs3789678 and rs2493132 within AGT, rs4305 within ACE, rs275645 within AGTR1, rs3802230 and rs10086846 within CYP11B2 were shown to associate with hypertension. The MDR analysis demonstrated that the interaction between BMI and rs4305 increased the susceptibility to hypertension. Crossover analysis and stratified analysis further indicated that BMI has a major effect, and rs4305 has a minor effect. CONCLUSION: These novel findings indicated that together with non-genetic factors, these genetic variants in the RAAS may play an important role in determining an individual's susceptibility to hypertension in the Han Chinese.
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Ji et al. (2013) conducted a case-control in Essential hypertension (n=1,810). RAAS gene polymorphisms (e.g., rs4305 in ACE) vs. Normotensive controls / Wild-type alleles was evaluated on Essential hypertension (OR 1.26, 95% CI 1.10-1.44, p=0.001). The rs4305 polymorphism in the ACE gene was associated with essential hypertension, and its interaction with a body mass index ≥25 further increased disease susceptibility.
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