January 1, 2010Circulation JournalOpen Access

A Genome-Wide Association Study of Hypertension-Related Phenotypes in a Japanese Population

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Population

936 Japanese participants from the Suita Study not receiving antihypertensive medication for initial…

Design

Cross-sectional

Authors

YHYumiko HiuraNational Cerebral and Cardiovascular Center YTYasuharu TabaraPreventive Cardiology YKYoshihiro KokuboPreventive Cardiology

Discussion

Member takes

Implication

No master BP gene identified; leaves open polygenic or environmental drivers while supporting ALDH2 and NPPB variant associations in Japanese cohorts.

Structured PICO

Population

936 Japanese participants from the Suita Study (age range 42-73 years) not receiving antihypertensive medication for initial screening, with validation in 3,228 participants from the Suita Study and 2,895 participants from the Nomura Study.

Outcome

Genome-wide significant associations of single nucleotide polymorphisms (SNPs) with hypertension-related phenotypes including systolic and diastolic blood pressure, BMI, waist-to-hip ratio, plasma renin activity, plasma aldosterone concentration, BNP, and alcohol consumption.surrogate

This genome-wide association study in a Japanese population found no single master gene for blood pressure regulation, but confirmed strong genetic determinants for alcohol consumption (ALDH2) and BNP levels (NPPB).

Limitations

Medium-sized population for initial screening, requiring much larger sample sizes to identify polymorphisms with minor to moderate influence
Potential underreporting of alcohol consumption among heavy drinkers

Cite This Study

Hiura et al. (2010) studied this question.

synapsesocial.com/papers/6a6f695afebe604dd708562f https://doi.org/10.1253/circj.cj-10-0353

Topics

Hypertension management

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Implication

No master BP gene identified; leaves open polygenic or environmental drivers while supporting ALDH2 and NPPB variant associations in Japanese cohorts.

A Genome-Wide Association Study of Hypertension-Related Phenotypes in a Japanese Population

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

A Genome-Wide Association Study of Hypertension-Related Phenotypes in a Japanese Population

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider