Why the study?
There is a paucity of evidence from genetic studies of resistant hypertension, particularly in Asian populations.
Population
2,705 resistant hypertension cases and 21,296 mild hypertension controls from BioBank Japan
Comparison
Resistant hypertension cases vs mild hypertension controls
Design
Genome-wide association study
Authors
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Should not change practice; leaves open validation and functional studies in Asian ancestry.
A genome-wide association study in a Japanese population identified a novel susceptibility locus at the DLGAP1 gene for resistant hypertension, highlighting the potential role of the nervous system in its etiology.
Takahashi et al. (2021) studied this question.
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