Key result
Specific single nucleotide polymorphisms in HPCAL1 in women and GREB1 in men were significantly associated with hypertension prevalence and blood pressure levels in a Japanese general population.
Why the study?
Are genetic polymorphisms in the chromosome 2p24-p25 region associated with hypertension susceptibility in a Japanese population?
Population
1880 individuals from a Japanese general population (796 hypertensive and 1084 normotensive)
Comparison
Genetic polymorphisms in the chromosome 2p24-p25… vs Alternative alleles/genotypes
Design
Cross-sectional
Authors
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May support sex-specific genetic risk assessment in Japanese adults; extends 2p24-p25 loci but remains hypothesis-generating without replication.
Observational (n=1,880)
Are genetic polymorphisms in the chromosome 2p24-p25 region associated with hypertension susceptibility in a Japanese population?
GREB1 and HPCAL1 are candidate hypertension-susceptibility genes in the Japanese general population, supporting previous findings of hypertension-related loci in the chromosome 2p24-p25 region.
Kamide et al. (2005) conducted an observational in Hypertension (n=1,880). Polymorphisms in chromosome 2p24-p25 (HPCAL1 and GREB1 genes) was evaluated on Prevalence of hypertension and blood pressure levels. Specific single nucleotide polymorphisms in HPCAL1 in women and GREB1 in men were significantly associated with hypertension prevalence and blood pressure levels in a Japanese general population.
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