Why the study?
Are CYBA, CLCNKB, and KCNMB1 functional polymorphisms associated with hypertension in the general Japanese population?
Population
3,652 subjects representing the general population in Japan (recruited from the Suita study)
Comparison
CYBA GA, CLCNKB T481S, and KCNMB1 E65K… vs Alternative genotypes of the same polymorphisms
Design
Cohort
Authors
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Supports CYBA variant as hypertension susceptibility factor in Japanese men; leaves open causal role and need for validation.
Are CYBA, CLCNKB, and KCNMB1 functional polymorphisms associated with hypertension in the general Japanese population?
The CYBA G(-930)A polymorphism is significantly associated with hypertension and higher blood pressure in Japanese men, suggesting a genetic susceptibility to hypertension.
Kokubo et al. (2005) studied this question.
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