Effectiveness of the α-tocopherol, ursodeoxycholic acid, and AZHEPOFIT phyto-complex against the statin model of drug-induced hepatitis

Background: Drug-induced hepatitis is a common and serious side effect of many medications. Treatment for this condition is often difficult and limited, and there is a need for effective treatment options. The aim of this study was to investigate the effectiveness of α-tocopherol acetate, ursodeoxycholic acid, and AZHEPOFIT phyto-complex against the background of a statin model of drug-induced hepatitis. Methods: The study was conducted on 70 white mongrel rats, divided into two groups and treated for 2 weeks twice a day. Statistical analysis was carried out by the Mann-Whitney-Wilcoxon method using MS EXCEL and S-PLUS software.Results: Against the background of the statin hepatitis model, the combined use of the phyto-complex and ursodeoxycholic acid showed the best results. The atherogenicity index decreased from 16.03 to 2.29, the De Ritis ratio decreased from up to 1.49±0.05, and the severity of lipid peroxidation, the content of c-reactive protein, and medium molecular weight peptides decreased. All of these results indicate the restoration of the functional state of the liver.Conclusion: The use of α-tocopherol acetate, ursodeoxycholic acid, and AZHEPOFIT phyto-complex can be an effective treatment option for drug-induced hepatitis caused by statin medication. The combination of phyto-complex and ursodeoxycholic acid showed the best results in reducing.Keywords: Statin drug-induced hepatitis; α-tocopherol acetate; Ursodeoxycholic acid; AZHEPOFIT phyto-complex; Atherogenicity index; De Ritis ratio Editorial Expression of Concern20 June 2025: Following publication of this paper, the internal audit (consequent to concerns on quality raised by Web of Science) notified Advancements in Life Sciences about problems in use of English language. By this Editorial Expression of Concern, we alert the scientific community as we address the errors.Editorial Note:26 June 2025: You are viewing the latest version of this article having minor corrections related to the use of English language. Expression of concern is hereby revoked.