Correlation between Pentraxin 3 level and some biomarkers in Type 2 Diabetes mellitus Iraqi patients

Background: Diabetes is a long-term metabolic disorder that has an impact on how your body utilizes glucose as an energy source. It can lead to a range of complications and damage to various organs in the body. These can include retinopathy. Diabetes Retinopathy (DR) is an eye-related complication of diabetes and is brought on by injury to the blood vessels feeding the retina. This can result in blindness.Methods: The study had 100 T2DM patients and 50 healthy controls with an age range of 40 to 80 years, and a disease duration of 1 to 30 years. The participants were divided into two groups DR and DWR and the control group. The study ran from November 2022 to January 2023 in the governorates of Diyala and Bagdad.Result: The mean levels of PTX3, Urea and FBG levels increase in the DR patients the statistical significance of these differences was very high (P>0.01). The patients' group also saw a highly significant rise in creatinine and a highly significant drop in GFR (P>0.01) when compared to the control.Conclusion: PTX3 and FBG levels have been shown to be elevated in people with DR compared to controls and DWR, and these levels have been found to be connected with the onset and severity of DR. While there is no clear link between urea and retinopathy. More study is needed, though, to fully understand the mechanisms underlying this association and determine whether PTX3 can be a useful diagnostic or therapeutic target for DR.