Non-ischemic cardiomyopathy after rituximab treatment for mucous membrane pemphigoid: a case report

We report a rare case of non-ischemic cardiomyopathy in a 62-year-old female with mucous membrane pemphigoid following rituximab therapy. The patient presented with dyspnea and chest pain, and cardiac evaluation-including transthoracic echocardiogram and nuclear medicine stress testing-revealed left ventricular dysfunction without evidence of ischemia. Given the temporal association and absence of other etiologies, rituximab was suspected as the causative agent. This case emphasizes the importance of recognizing the potential cardiotoxic effects of biological agents used in autoimmune disease management and supports the consideration of cardiac surveillance in at-risk patients receiving rituximab.