Key result
A 56-year-old man developed reversible dilated cardiomyopathy and hypotensive shock following one cycle of rituximab and bendamustine for chronic lymphocytic leukemia.
Case Report (n=1)
This case highlights the potential for reversible dilated cardiomyopathy following rituximab therapy, emphasizing the need for cardiovascular monitoring.
May warrant cardiac monitoring with rituximab in CLL; leaves open causality and need for prospective studies.
INTRODUCTION: Rituximab is a monoclonal antibody that has shown efficacy in non-Hodgkin's lymphoma, chronic lymphocytic leukemia (CLL), both as a single agent and in combination with traditional chemotherapies. CASE REPORT: Here, we present a case wherein a 56-year-old man developed dilated cardiomyopathy following one cycle of rituximab and bendamustine chemotherapy protocol used to treat chronic lymphocytic leukemia. On the fifth day the patient developed hypotensive shock followed closely by the development of cough after two days. MANAGEMENT AND OUTCOME: The patient was started on carvedilol 3.125 mg, ramipril 2.5 mg, and torsemide 5 mg for treatment of cardiomyopathy. Blood transfusion was necessary for hypotensive shock. Antibiotic regimen was started for sepsis and progressive cough. The patient recovered fully from all the symptoms. DISCUSSION: This case illustrates the potential for cardiomyopathy with rituximab, particularly in patients with chronic lymphocytic leukemia, and its proposed mechanisms and treatment. The expanding utility of rituximab impels us to increase monitoring and awareness of this serious cardiovascular adverse effect.
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Girkar et al. (2022) conducted a case report in Chronic lymphocytic leukemia (n=1). Rituximab and bendamustine was evaluated on Dilated cardiomyopathy. A 56-year-old man developed reversible dilated cardiomyopathy and hypotensive shock following one cycle of rituximab and bendamustine for chronic lymphocytic leukemia.
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