Key result
Rituximab is linked to adverse cardiac events, especially arrhythmia and angina in patients with prior CVD.
Why the study?
The detailed cardiotoxicity profile, effects on cardiac function, and management of rituximab's cardiac side effects are not well described in the literature.
Does rituximab cause adverse cardiac effects in patients treated for inflammatory and malignant conditions?
Does rituximab cause adverse cardiac effects in patients treated for inflammatory and malignant conditions?
Physicians prescribing rituximab should be aware of its potential to cause serious cardiovascular adverse effects, including arrhythmias and angina.
Answers are grounded in this paper and cite their sources.
Rituximab infusion requires cardiac monitoring in at-risk patients; Level 5 data leave open the need for prospective safety confirmation in dermatology.
Rituximab is an anti-CD20 monoclonal antibody frequently used for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, and anti-neutrophilic cytoplasmic antibody-associated vasculitis. In addition, rituximab has recently been increasingly used as an off-label treatment in a number of inflammatory and systemic autoimmune diseases. Its side effect profile includes infusion-related reactions and adverse cardiac effects such as arrhythmia and angina, particularly in patients with prior history of cardiovascular diseases. However, its detailed cardiotoxicity profile, effects on cardiac function, and its management are not well described in the literature. As the utility of rituximab expands, primary physicians, intensivist, dermatologist who use drug should be made of these serious cardiovascular adverse effect.
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Patil et al. (2020) conducted a review in Patients receiving rituximab. Rituximab was evaluated on Adverse cardiac effects (arrhythmia and angina). Rituximab use is associated with adverse cardiac effects such as arrhythmia and angina, particularly in patients with a prior history of cardiovascular diseases.
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