Rituximab-Induced Vasculitis: A Case Report and Literature Review

IntroductionRituximab is an anti-CD20 chimeric human-murine monoclonal antibody that is effective in the treatment of some autoimmune diseases.Cutaneous vasculitis is an unusual side effect of rituximab, with only a few reported cases worldwide. Case presentationA 51-year-old male presented with constitutional symptoms and symmetrical palpable erythematous lesions mainly on the lower extremities after one month of using rituximab.This scenario was very impressive because of the scarcity of this type of drug side effect.However, full investigations including histopathology were done, and after the exclusion of all other causes, a diagnosis of cutaneous vasculitis was made.Fortunately, the symptoms were relieved after drug discontinuation. ConclusionCutaneous vasculitis is rare but a real side effect of rituximab, which usually subsides after stopping the drug.