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August 1, 2025The International Journal of NeuropsychopharmacologyOpen Access

Distinct and Common Subcortical Functional Connectivity Revealed Across Three Major Psychiatric Disorders

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Authors

DHD. HungWCWC ChangTaipei Veterans General HospitalMCM-H Chen

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Implication

Observational analysis reveals altered functional connectivity in psychiatric disorders, suggesting shared and unique pathways.

Key Points

  • Patients with schizophrenia showed distinct functional connectivity patterns, with increased connections in the striatum and limbic networks.
  • Bipolar disorder exhibited unique decreased connectivity between thalamus and hippocampal-amygdala regions, while still sharing hypoconnectivity with schizophrenia.
  • Major depressive disorder participants displayed no significant increases in connectivity but reduced connections between key subcortical areas.
  • This research highlights the complex functional relationships within subcortical regions, indicating potential targets for future treatments.

Cite This Study

Hung et al. (2025) studied this question.

synapsesocial.com/papers/68af4314ad7bf08b1ead16f2https://doi.org/10.1093/ijnp/pyaf052.211
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Distinct and common subcortical functional connectivity revealed across three major psychiatric disorders2026 · 2 citations
  2. 2Shared subcortical–default mode morphological dysconnectivity in adolescent bipolar disorder, major depressive disorder and schizophrenia2026
  3. 3Disorganized functional architecture of hippocampal subregional networks in major depressive disorder2025
  4. 4Phenomena of hypo- and hyperconnectivity in basal ganglia-thalamo-cortical circuits linked to major depression: a 7T fMRI study2024 · 18 citations
  5. 5Impaired Cortico-Thalamo-Cerebellar Integration Across Schizophrenia, Bipolar II, and Attention Deficit Hyperactivity Disorder Patients Suggests Potential Neural Signatures for Psychiatric Illness2024