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This is a Quantitative Study study.

Disorganized functional architecture of hippocampal subregional networks in major depressive disorder

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Data-driven analysis reveals altered functional connectivity in hippocampal subregions related to MDD, indicating potential clinical implications.

Enhanced connectivity in the rostral hippocampus was observed in patients with major depressive disorder.
A two-cluster model effectively represented the hippocampal architecture, identifying rostral and caudal subregions.
Data-driven connectivity analysis revealed significant relationships between hippocampal networks and clinical symptoms.
Findings suggest functional segregation of the hippocampus along its long axis and highlight connectivity alterations in MDD.

Tang et al. (2025) studied this question.

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Data-driven analysis reveals altered functional connectivity in hippocampal subregions related to MDD, indicating potential clinical implications.