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September 10, 2025Open Access

Reduced functional segregation of insular connectivity profiles in depression

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Observational analysis reveals impaired functional connectivity in insular subregions in MDD, indicating significant clinical implications.

Greater similarity in functional connectivity profiles of insular subregions was found in major depressive disorder compared to healthy controls.
The anterior insular cortex showed decreased specificity and increased density of functional connectivity in individuals with MDD.
Resting-state fMRI in 433 patients with MDD highlighted alterations in interoceptive signals, suggesting a link to homeostatic processes.
Functional segregation of insular regions may serve as a clinically relevant index of depression severity and pathophysiology.

Teckentrup et al. (2025) studied this question.

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Observational analysis reveals impaired functional connectivity in insular subregions in MDD, indicating significant clinical implications.