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April 19, 2026Frontiers in PsychiatryOpen Access

Functional connectivity gradients of the insula in major depressive disorder

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The aim is to investigate the functional connectivity gradients of the insula in major depressive disorder (MDD) patients compared to healthy controls.
Collected resting-state functional MRI data from 38 MDD patients and 34 healthy controls
Analyzed functional connectivity gradients at three levels: whole-brain, insula-to-whole-brain, and insula-to-seven-brain-networks
The whole-brain gradient distinguished transmodal from unimodal regions in both groups.
MDD patients showed a less distinct separation between anterior and posterior insular regions.
The insula's relationship with the dorsal attention network was more specialized in MDD patients.

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Reveals altered insula connectivity gradients in major depressive disorder compared to healthy controls, suggesting implications for treatment.

Burhanoğlu et al. (2026) studied this question.

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Reveals altered insula connectivity gradients in major depressive disorder compared to healthy controls, suggesting implications for treatment.