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August 18, 2025BiologyOpen Access

Paternal Cocaine Exposure and Its Testicular Legacy: Epigenetic, Physiological, and Intergenerational Consequences

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Authors

CGCandela R. GonzálezBGBetina González

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Overview

Review reveals cocaine disrupts reproductive physiology and epigenetic programming in males, suggesting intergenerational impacts.

Key Points

  • Paternal cocaine exposure leads to significant alterations in testicular function and offspring behavior.
  • Approximately two-thirds of regular cocaine users are males of reproductive age, highlighting a public health concern.
  • Epidemiological studies indicate that cocaine disrupts spermatogenesis and induces germline epimutations.
  • This review uncovers the links between cocaine's effects on male reproductive health and potential intergenerational consequences.

Cite This Study

González et al. (2025) studied this question.

synapsesocial.com/papers/68af431bad7bf08b1ead19achttps://doi.org/10.3390/biology14081072
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  1. 1Molecular mechanisms of cocaine reward: Combined dopamine and serotonin transporter knockouts eliminate cocaine place preference2001 · 477 citations
  2. 2Presence of Corticotrophin‐Releasing Factor and /or Tyrosine Hydroxylase in Cells of a Neural Brain‐Testicular Pathway That are Labelled by a Transganglionic Tracer2007 · 20 citations