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August 18, 2025Nature CommunicationsOpen Access

CENcyclopedia: dynamic landscape of kinetochore architecture throughout the cell cycle

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Authors

YCYu‐Chia ChenEKEce KilicEWEvelyn Wang

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Overview

Quantitative immunofluorescence reveals microtubule dynamics in kinetochores during the cell cycle, suggesting novel regulatory mechanisms.

Key Points

  • Kinetochore architecture changes throughout the cell cycle, impacting chromosome segregation in cells.
  • Dynamic interactions with microtubules are pivotal for maintaining proper kinetochore function and fidelity.
  • Assessment used advanced quantitative immunofluorescence techniques to analyze protein levels over the cell cycle.
  • These findings may enable deeper insights into kinetochores' regulatory mechanisms and their role in cell division.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68af431bad7bf08b1ead1a3chttps://doi.org/10.1038/s41467-025-62316-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Direct observation of interdependent and hierarchical kinetochore assembly on individual centromeres2025
  2. 2Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast2024
  3. 3BPS2026 – Mammalian metaphase kinetochores are deformable, elastic materials dependent on condensin for structural robustness and functional integrity2026
  4. 4Centromeric chromatin clearings demarcate the site of kinetochore formation2024 · 1 citations
  5. 5Architecture of native kinetochores revealed by structural studies utilizing a thermophilic yeast2024 · 5 citations