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February 21, 2026Biophysical Journal

BPS2026 – Mammalian metaphase kinetochores are deformable, elastic materials dependent on condensin for structural robustness and functional integrity

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Authors

VTVanna M. TranJTJinghui TaoCRCaleb J. Rux

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Overview

Super resolution microscopy reveals that mammalian kinetochores deform under forces, indicating condensin's role in stability.

Key Points

  • This study aims to explore the structural properties and functional integrity of mammalian kinetochores under force during metaphase.
  • Used super resolution microscopy to observe kinetochore deformations during metaphase
  • Applied microneedle pulling forces to assess elasticity and stability
  • Evaluated the effects of SMC2 depletion on kinetochore behavior
  • Kinetochores exhibited significant elastic deformations under force
  • Variable deformations observed with SMC2 depletion, despite elasticity being maintained
  • Kinetochore structural integrity is crucial for stable microtubule attachment

Cite This Study

Tran et al. (2026) studied this question.

synapsesocial.com/papers/69990e0a5b97ab4c14ac2fd6https://doi.org/10.1016/j.bpj.2025.11.2043
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast2024
  2. 2Bayesian data driven modelling of kinetochore dynamics: Space-time organisation of the human metaphase plate2026
  3. 3CENcyclopedia: dynamic landscape of kinetochore architecture throughout the cell cycle2025
  4. 4Direct observation of interdependent and hierarchical kinetochore assembly on individual centromeres2025
  5. 5BPS2026 – Mechanical force locally damages, remodels, and stabilizes the lattice of spindle microtubules2026