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October 17, 2025Nucleic Acids ResearchOpen Access

Direct observation of interdependent and hierarchical kinetochore assembly on individual centromeres

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Authors

CHChangkun HuAPAndrew R. PopchockALAngelica Andrade Latino

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Overview

Direct observation reveals interdependencies in kinetochore assembly in budding yeast, indicating regulatory importance.

Key Points

  • Kinetochore assembly shows interdependencies among subcomplexes, affecting their assembly order.
  • The assembly of inner kinetochores relies partly on outer kinetochore components, highlighting a complex relationship.
  • Mif2 is identified as a rate-limiting factor in kinetochore assembly, crucial for efficient chromosome segregation.
  • Overexpression of the centromeric histone variant Cse4 leads to defective attachments without proper kinetochore regulation.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/68f199d1de32064e504dd77ahttps://doi.org/10.1093/nar/gkaf1038
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