August 1, 2025PlasmidOpen Access

Insights from public database sequences related to the replication initiation protein TrfA of the IncP-1 plasmid RK2

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Phylogenetic analysis reveals diverse TrfA homologs in various taxa, suggesting caution in single-gene replicon typing.

Detecting specific plasmid groups solely using single-gene replicon typing may lead to inaccurate conclusions, cautioning against overreliance.
Phylogenetic trees illustrate TrfA homologs show divergence from vertical inheritance and horizontal gene transfer across taxa.
Analysis identified 76 candidate IncP-1 plasmids by screening trfA-harboring sequences against the nr nucleotide database.
TrfA-matched sequences were found in diverse taxonomic groups, including plasmids and bacterial chromosomes.

Suzuki et al. (2025) studied this question.

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