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August 18, 2025Open Access

Figure S3 from PSA Secretion from Single Circulating Tumor Cells of Metastatic Castration-Naïve Prostate Cancer Patients

Eshwari Dathathri Fikri Abali Michiel Stevens Richell Booijink Tanja C. van Dijk Khrystany T. Isebia John W.M. Martens Jaco Kraan Nick Beije Martijn P. Lolkema Peter A.W. te Boekhorst Paul Hamberg Brigitte C.M. Haberkorn Danny Houtsma Joan van den Bosch Wendy M. van der Deure Ruchi Bansal Leon W.M.M. Terstappen

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Key Points

PSA secretion was effectively visualized from individual circulating tumor cells (CTCs), showcasing tumor-specific activity.
Analysis included printing PSA proteins onto PVDF membranes to facilitate matching with CTCs for deeper insights.
The process employed nanowell arrays, enhancing the ability to monitor single-cell behavior and characteristics effectively.
Findings support the potential for isolating viable CTCs for further investigations into prostate cancer progression.

Implication

Visualization of PSA secretion from circulating tumor cells, highlighting key methods for analysis.

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Cite This Study

Dathathri et al. (2025) studied this question.

synapsesocial.com/papers/68af4328ad7bf08b1ead2228 https://doi.org/10.1158/2767-9764.29929861

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure 5 from PSA Secretion from Single Circulating Tumor Cells of Metastatic Castration-Naïve Prostate Cancer Patients2025
2Figure 4 from PSA Secretion from Single Circulating Tumor Cells of Metastatic Castration-Naïve Prostate Cancer Patients2025
3Figure S5 from PSA Secretion from Single Circulating Tumor Cells of Metastatic Castration-Naïve Prostate Cancer Patients2025
4Figure 2 from PSA Secretion from Single Circulating Tumor Cells of Metastatic Castration-Naïve Prostate Cancer Patients2025
5Figure 6 from PSA Secretion from Single Circulating Tumor Cells of Metastatic Castration-Naïve Prostate Cancer Patients2025