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August 19, 2025Translational PsychiatryOpen Access

Prenatal maternal HFD exposure impairs cognition via a hippocampal NMDA mechanism

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Authors

KCKuan-Ru ChenYHYu-Cheng HoCHChih‐Wei Huang

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Overview

Observational analysis shows impaired cognition and behavioral abnormalities in offspring due to maternal obesity, highlighting NMDA receptor involvement.

Key Points

  • Maternal high-fat diet exposure in utero impairs spatial working memory and induces depression-like behavior in offspring.
  • Key evidence shows reduced hippocampal NMDA receptor expression and deficits in long-term potentiation in affected offspring.
  • Behavioral tests conducted between postnatal days 42 and 56 revealed significant cognitive impairments, suggesting a critical developmental window.
  • Findings support the need for further research on maternal diet's role in neurodevelopment, particularly regarding NMDA receptor signaling.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68af453aad7bf08b1ead282ahttps://doi.org/10.1038/s41398-025-03520-2
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