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September 10, 2025Translational PsychiatryOpen Access

Sex-dependent preventive effects of prenatal N-acetyl-cysteine on neuronal, emotional and metabolic dysfunctions following exposure to maternal high-fat diet in mice

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Authors

CMChiara MusilloIstituto Superiore di Sanità MSMaria Teresa SamàUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”KCKerstin Camile CreutzbergUniversity of Milan

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Implication

Observational analysis shows prenatal N-acetyl-cysteine prevents cognitive impairments in offspring, indicating potential protective mechanisms against maternal high-fat diets.

Key Points

Prenatal N-acetyl-cysteine prevented anxiety-like behaviors and cognitive impairments in adult mouse offspring.
Results highlighted significant downregulation of BDNF in response to maternal high-fat diet exposure.
Approach included assessments of behavioral, metabolic, and gene expression responses in a mouse model.
Findings suggest rebalancing redox status may buffer negative effects of early adverse experiences.

Cite This Study

Musillo et al. (2025) studied this question.

synapsesocial.com/papers/68c1ce7b54b1d3bfb60f5ee5 https://doi.org/10.1038/s41398-025-03530-0

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Implication

Observational analysis shows prenatal N-acetyl-cysteine prevents cognitive impairments in offspring, indicating potential protective mechanisms against maternal high-fat diets.

Sex-dependent preventive effects of prenatal N-acetyl-cysteine on neuronal, emotional and metabolic dysfunctions following exposure to maternal high-fat diet in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Sex-dependent preventive effects of prenatal N-acetyl-cysteine on neuronal, emotional and metabolic dysfunctions following exposure to maternal high-fat diet in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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