In-depth Structural Characterization of Sphingoid Bases via Derivatization and Electron-Activated Dissociation Tandem Mass Spectrometry

Xiaohui Zhang; Xue Zhao

doi:10.1039/d5an00637f

January 1, 2025The Analyst

In-depth Structural Characterization of Sphingoid Bases via Derivatization and Electron-Activated Dissociation Tandem Mass Spectrometry

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Key Points

The study identifies the structural diversity of sphingoid bases through tandem mass spectrometry, confirming their crucial role in sphingolipid diversity.
Electron-activated dissociation tandem mass spectrometry effectively characterizes intrachain modifications such as carbon-carbon double bonds and hydroxyl groups.
Derivatization techniques enhance the analysis of sphingoid bases, allowing for detailed structural characterization of sphingolipids.
Understanding sphingoid base diversity may lead to insights into various biological functions and roles of sphingolipids.

Implication

This analysis reveals the diversity of sphingoid bases in sphingolipids, indicating their structural complexity and modifications.

Abstract

Sphingoid bases (SPHs) serve as the core structural backbone of all sphingolipid classes, with their diversity arising from intrachain modifications such as carbon-carbon double bonds (C=C), hydroxyl groups, and methyl...

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68af453aad7bf08b1ead28a0 https://doi.org/10.1039/d5an00637f

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In-depth Structural Characterization of Sphingoid Bases via Derivatization and Electron-Activated Dissociation Tandem Mass Spectrometry

Key Points

Implication

Abstract

Discussion

Cite This Study

In-depth Structural Characterization of Sphingoid Bases via Derivatization and Electron-Activated Dissociation Tandem Mass Spectrometry

Key Points

Implication

Abstract

Discussion

Cite This Study

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