What question did this study set out to answer?

Develop a quantitative analytical method to detect typical and atypical sphingoid bases and their N-acyl metabolites, and measure their presence across various edible food sources.

October 22, 2019Journal of Agricultural and Food Chemistry

Analysis of 1-Deoxysphingoid Bases and Their N-Acyl Metabolites and Exploration of Their Occurrence in Some Food Materials

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Authors

JWJunliang WanNanchang University JLJian LiFirst Affiliated Hospital of Gannan Medical University SBSibali BandyopadhyayGeorgia Institute of Technology

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Implication

Analytical study reveals variable levels of atypical 1-deoxysphingolipids across diverse food materials, highlighting potential dietary impacts on human health.

Key Points

Develop a quantitative analytical method to detect typical and atypical sphingoid bases and their N-acyl metabolites, and measure their presence across various edible food sources.
Developed a targeted profiling method using reverse-phase liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS).
Quantified typical sphingoid bases, atypical 1-deoxy- and 1-desoxymethylsphingoid bases, and their corresponding N-acyl derivatives across various edible materials.
Observed wide qualitative and quantitative variation in atypical sphingoid base species and their N-acyl metabolites across tested edible sources.
Identified that dietary materials supply diverse atypical sphingolipid subspecies, indicating that human diets serve as an exogenous exposure source for biologically active sphingolipids.

Cite This Study

Wan et al. (2019) studied this question.

synapsesocial.com/papers/6aae2ade42aeb2f8a66386ea https://doi.org/10.1021/acs.jafc.9b05708

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Implication

Analytical study reveals variable levels of atypical 1-deoxysphingolipids across diverse food materials, highlighting potential dietary impacts on human health.

Analysis of 1-Deoxysphingoid Bases and Their N-Acyl Metabolites and Exploration of Their Occurrence in Some Food Materials

Discussion

Member takes

Implication

Key Points

Cite This Study

Analysis of 1-Deoxysphingoid Bases and Their N-Acyl Metabolites and Exploration of Their Occurrence in Some Food Materials

Discussion

Member takes

Implication

Key Points

Cite This Study

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