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August 17, 2025Digestive Endoscopy

Impact of Glucagon‐Like Peptide‐1 Receptor Agonists on Retained Gastric Contents During Esophagogastroduodenoscopy: A Propensity Score‐Matched Study

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Authors

HHHiroyuki HisadaYTYosuke TsujiDKDai Kubota

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Overview

Retrospective analysis identifies glucagon-like peptide-1 receptor agonists increased retained gastric contents in Asian diabetes patients, suggesting clinical precautions may be essential.

Key Points

  • Retained gastric contents occurred more frequently in patients using glucagon-like peptide-1 receptor agonists during EGD, indicating a significant risk.
  • In the GLP-1 RA group, RGC happened in 12.2% of cases after matching, compared to 3.4% in the non-GLP-1 RA group, showing a notable difference.
  • Assessment involved propensity score matching of 148 patients on GLP-1 RA and 148 not on it, reflecting rigorous methodology.
  • These findings support the need for precautions like a liquid diet prior to EGD to reduce risks associated with gastric retention.

Cite This Study

Hisada et al. (2025) studied this question.

synapsesocial.com/papers/68af453fad7bf08b1ead2b3bhttps://doi.org/10.1111/den.70016
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