What question did this study set out to answer?

To evaluate the safety of glucagon-like peptide-1 receptor agonists during upper endoscopy, focusing on gastric retention and procedural outcomes.

Evaluating Glucagon-Like Peptide-1 Receptor Agonist Safety Before Upper Endoscopy: A Systematic Review and Meta-Analysis

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Systematic review finds GLP-1 RAs linked to higher gastric retention in individuals undergoing endoscopy, suggesting caution.

To evaluate the safety of glucagon-like peptide-1 receptor agonists during upper endoscopy, focusing on gastric retention and procedural outcomes.
Comprehensive search across multiple databases for comparative studies on GLP-1 RA exposure vs non-exposure
Primary outcome: presence of retained gastric contents, secondary outcomes: aspiration risk and repeated esophagogastroduodenoscopy
Included 28 studies with data from 212,082 individuals collected from 2015 to 2023.
GLP-1 RA use associated with 3.95 odds ratio (OR) for retained gastric contents, P < 0.0001
No increased odds of aspiration (OR: 1.09, P = 0.145) or repeated endoscopies (OR: 1.82, P = 0.145)
Significant association with procedure cancellation (OR: 3.96, P < 0.0001).

Ahmed et al. (2026) studied this question.

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