What question did this study set out to answer?

This review aims to connect GLP-1 receptor agonist therapy with gastric motility changes and their implications for endoscopic procedures.

June 19, 2026Chronic Diseases and Translational MedicineOpen Access

GLP‐1 Receptor Agonists and Endoscopy: Understanding Gastric Stasis, Aspiration Risk, and Contemporary Peri‐Procedural Guidance

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Authors

JBJunaid BeigRoyal Hobart Hospital JTJason TaUniversity of Tasmania SJSophie JonesRoyal Hobart Hospital

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Implication

Review discusses GLP-1 receptor agonists' effects on gastric stasis and aspiration risk during gastrointestinal endoscopy, suggesting evidence-based guidelines.

Key Points

This review aims to connect GLP-1 receptor agonist therapy with gastric motility changes and their implications for endoscopic procedures.
Synthesis of mechanistic, physiological, and clinical evidence regarding GLP-1RA therapy and gastric motility.
Combination of data from pharmacological studies, scintigraphic evaluations, and large observational cohorts.
Review of international consensus statements to guide peri-procedural decisions.
GLP-1RA exposure is linked to a higher incidence of retained gastric contents during endoscopy.
Aspiration rates for GLP-1RA users undergoing colonoscopy were approximately 0.01%-0.05%.
Only a small increase in aspiration-related events occurred during upper gastrointestinal endoscopy, with fewer than 0.3% reporting such events.

Cite This Study

Beig et al. (2026) studied this question.

synapsesocial.com/papers/6a34dde465a5b0777af2d782 https://doi.org/10.1002/cdt3.70059

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Implication

Review discusses GLP-1 receptor agonists' effects on gastric stasis and aspiration risk during gastrointestinal endoscopy, suggesting evidence-based guidelines.

GLP‐1 Receptor Agonists and Endoscopy: Understanding Gastric Stasis, Aspiration Risk, and Contemporary Peri‐Procedural Guidance

Discussion

Member takes

Implication

Key Points

Cite This Study

GLP‐1 Receptor Agonists and Endoscopy: Understanding Gastric Stasis, Aspiration Risk, and Contemporary Peri‐Procedural Guidance

Discussion

Member takes

Implication

Key Points

Cite This Study

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