January 1, 2025BIO IntegrationOpen Access

Mechanistic Insights and Therapeutic Potential of Quercetin in Neuroprotection: A Comprehensive Review of Pathways and Clinical Perspectives

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Quercetin offers significant neuroprotective effects against neurodegenerative diseases, enhancing cognitive function and neuronal integrity.
Key mechanisms include antioxidant activity via the Nrf2-ARE pathway and modulation of PI3K/Akt pathway for mitochondrial health.
Observational analysis incorporates insights from preclinical studies on quercetin's efficacy and its synergy with pharmacologic agents.
Advancing personalized medicine, this review discusses innovative strategies to enhance quercetin's bioavailability and therapeutic applicability.

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Comprehensive review highlights quercetin's neuroprotective effects in neurodegenerative diseases, suggesting innovative therapeutic approaches.

Debnath et al. (2025) studied this question.

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Comprehensive review highlights quercetin's neuroprotective effects in neurodegenerative diseases, suggesting innovative therapeutic approaches.