Cerebral ischaemia-reperfusion injury (CIRI) is a significant contributor to neurological dysfunction following ischemic stroke, involving multiple pathological mechanisms such as immune disorder, oxidative stress, inflammatory response, and apoptosis. Quercetin, a flavonoid compound widely present in fruits, vegetables, and grains, exhibits multiple biological activities including antioxidant, anti-inflammatory, antiviral, and anti-tumor properties, and has demonstrated significant neuroprotective effects in CIRI models. Currently, systematic reviews on quercetin’s antagonistic effects against CIRI are scarce, and its precise mechanism of action and clinical translational potential remain to be further explored. This article systematically reviews the multidimensional protective mechanisms of quercetin against CIRI, focusing on its action pathways in four dimensions: immune regulation, cell protection, organelle homeostasis maintenance, and blood-brain barrier (BBB) protection. Additionally, it discusses the clinical application prospects, safety, and existing challenges of quercetin, aiming to provide a theoretical basis for subsequent research on quercetin as a neuroprotective strategy and promote its clinical translation in the prevention and treatment of CIRI.
Wang et al. (Thu,) studied this question.
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