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This is a In Vitro Study study.

August 18, 2025Organic LettersOpen Access

Enantioselective NHC-Catalyzed Annulation via Umpolung for the Construction of Hydroxylamine Architectures with Variable Ring Sizes

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The method delivers diverse chiral hydroxylamine heterocycles with yields up to 99%.
Enantioselectivities exceed 99% ee, showcasing the efficiency of the NHC-catalyzed reaction.
This organocatalytic approach uses keto-oxime ethers, overcoming challenges in their electrophilicity.
This metal-free strategy expands the reactivity of keto-oximes in asymmetric catalysis.

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Organocatalytic method constructs chiral hydroxylamine frameworks, achieving high yields and selectivity.

Barańska et al. (2025) studied this question.

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